This work is about a female guru who experiments on human bodies and a woman who dropped out of pharmaceutical college and has a keen interest in internal organs. Guru (Saryu Usui) is a female guide who opened the Guru Lab to study people with worries. Based on her theory that the source of human sensuality is not the brain but the large intestine, she argues that simultaneous stimulation of the tongue in the oral cavity, the entrance to the digestive system, and the anus, the exit, can activate the internal organs. In order to put her ideas into practice, she preached her teachings to the people gathered in the lab while conducting human experiments. Meanwhile, Miss Looper (Rin Azuma), quits pharmaceutical university after a girl's thallium incident, but she has always been interested in the internal organs of the human body, and one day she meets Guru and becomes her assistant. She'll be helping with that research...