Columbia Pictures elevated a run-of-the-mill B-western supporting player, Marshall Reed, to the title role in this equally run-of-the-mill western serial released in 15 chapters. Like most serials in the '50s, Riding with Buffalo Bill consisted of quite a bit of budget-stretching stock footage telling a highly fictionalized account of Buffalo Bill Cody aiding a group of ranchers in their defeat of a local crime lord. The serial's assistant director, Leonard Katzman, later produced the long-running television series Gunsmoke and Dallas.