A young man who is suffering from a rare blood disease amputates his hand in an attempt to get rid of the disease. He dumps his hand into the river, which floats to a nearby spot where squash grows from the ground. The young man's blood seeps into the squash, thus bringing it to life. Meanwhile, a man looking for Thanksgiving dinner for him and his wife encounters the sentient, murderous squash. Will the squash become his dinner? Or will the man become dinner himself?