Home Sweetie Home follows the story of Romeo Valentino (John Lloyd Cruz) and Julie Matahimik (Toni Gonzaga) who lived together under one roof. Julie's mother Loi (Sandy Andolong) disapproves Romeo as her son-in-law because of his reputation as a womanizer, and prefers Jay-Jay (Jayson Gainza) whom she considers fit for her daughter, seeing him as responsible. Still, Romeo and Julie decide to marry each other. However, in turn, Romeo has to deal with Julie's family in the best way he knows how.